Sumit Sahni Selected Research

Thiosemicarbazones

1/2019	Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents.
1/2018	Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.
10/2017	A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.
5/2016	Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.
1/2016	The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways.
1/2016	Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.
10/2015	The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.
4/2014	The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.

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Sumit Sahni Research Topics

Disease

37	Neoplasms (Cancer) 01/2022 - 12/2011
15	Neoplasm Metastasis (Metastasis) 01/2021 - 09/2013
7	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 01/2015
7	Adenocarcinoma 11/2021 - 01/2015
3	Alzheimer Disease (Alzheimer's Disease) 10/2017 - 08/2014
2	Triple Negative Breast Neoplasms 01/2022 - 01/2021
2	Hypoxia (Hypoxemia) 01/2018 - 12/2011
2	Prostatic Neoplasms (Prostate Cancer) 05/2016 - 01/2015
2	Parkinson Disease (Parkinson's Disease) 02/2015 - 08/2014
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Margins of Excision 06/2021
1	Pancreatic Fistula (Pancreatic Fistulas) 06/2021
1	Disease Progression 12/2020
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2019
1	Starvation 01/2018
1	Colonic Neoplasms (Colon Cancer) 05/2016
1	Melanoma (Melanoma, Malignant) 04/2016
1	Friedreich Ataxia (Friedreich's Ataxia) 01/2016
1	Ataxia (Dyssynergia) 01/2016
1	Acne Vulgaris 03/2015
1	Huntington Disease (Huntington's Disease) 02/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2015
1	Carcinoma (Carcinomatosis) 01/2015
1	Adenocarcinoma of Lung 01/2015
1	Leukemia 01/2015
1	Virus Diseases (Viral Diseases) 08/2014
1	Nervous System Diseases (Neurological Disorders) 08/2014

Drug/Important Bio-Agent (IBA)

12	IronIBA 01/2017 - 12/2011
9	di- 2- pyridylketone- 4,4- dimethyl- 3- thiosemicarbazoneIBA 01/2020 - 11/2013
8	Proteins (Proteins, Gene)FDA Link 12/2020 - 12/2011
8	ThiosemicarbazonesIBA 01/2019 - 04/2014
7	Biomarkers (Surrogate Marker)IBA 11/2021 - 01/2020
7	Chelating AgentsIBA 12/2016 - 12/2011
6	CopperIBA 12/2016 - 10/2015
5	MetalsIBA 01/2019 - 01/2015
3	ErbB Receptors (EGF Receptor)IBA 01/2021 - 01/2016
3	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2018 - 04/2015
3	Pharmaceutical PreparationsIBA 01/2018 - 04/2015
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2018 - 12/2011
3	Phosphotransferases (Kinase)IBA 12/2016 - 09/2013
2	human ERBB2 proteinIBA 01/2022 - 01/2016
2	CateninsIBA 01/2022 - 09/2013
2	Gemcitabine FDA Link 01/2021 - 01/2020
2	Antineoplastic Agents (Antineoplastics)IBA 01/2019 - 12/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 07/2016
2	di-2-pyridylketone 4- cyclohexyl- 4- methyl- 3- thiosemicarbazoneIBA 01/2016 - 01/2015
2	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2016 - 10/2015
1	CytokinesIBA 01/2022
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022
1	TenascinIBA 01/2022
1	CreatineIBA 11/2021
1	trigonellineIBA 11/2021
1	hippuric acidIBA 11/2021
1	Inositol (Myoinositol)IBA 11/2021
1	glycolic acid (glycolate)IBA 11/2021
1	acetolIBA 11/2021
1	Eosine Yellowish-(YS) (Eosin)IBA 06/2021
1	Hematoxylin (Haematoxylon)IBA 06/2021
1	Insulin-Like PeptidesIBA 01/2021
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2021
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2021
1	Protein Isoforms (Isoforms)IBA 01/2019
1	AntioxidantsIBA 01/2019
1	Glucose (Dextrose)FDA LinkGeneric 01/2018
1	dithiolIBA 12/2016
1	multidrug resistance-associated protein 1IBA 12/2016
1	Glutathione Transferase (Glutathione S-Transferase)IBA 12/2016
1	CholesterolIBA 07/2016
1	3- beta- (2- (diethylamino)ethoxy)androst- 5- en- 17- oneIBA 07/2016
1	CollagenIBA 05/2016
1	Focal Adhesion Protein-Tyrosine KinasesIBA 05/2016
1	PaxillinIBA 05/2016
1	Neoplasm Antigens (Tumor Antigens)IBA 04/2016
1	Transferrin (beta 2 Transferrin)IBA 01/2016
1	Ferritins (Ferritin)IBA 01/2016
1	FrataxinIBA 01/2016
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 01/2016
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2015
1	tyrosine receptor (receptor, tyrosine)IBA 11/2015
1	IntegrinsIBA 11/2015
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 11/2015
1	DNA (Deoxyribonucleic Acid)IBA 10/2015
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 10/2015
1	Cyclin D1IBA 10/2015
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2015
1	Human Serum Albumin FDA LinkGeneric 04/2015
1	Anti-Infective Agents (Microbicides)IBA 03/2015
1	Therapeutic UsesIBA 03/2015
1	SemicarbazonesIBA 01/2015
1	Deferoxamine (Desferal)FDA LinkGeneric 01/2015
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2015
1	LigandsIBA 01/2015
1	InterleukinsIBA 01/2015
1	Beclin-1IBA 08/2014

Therapy/Procedure

12	Therapeutics 01/2021 - 01/2014
4	Neoadjuvant Therapy 06/2021 - 01/2020
3	Drug Therapy (Chemotherapy) 01/2021 - 11/2013
1	Pancreaticoduodenectomy 06/2021
1	Pancreatectomy 06/2021
1	Adjuvant Chemotherapy 01/2020